Synthesis and uptake of nitric oxide-releasing drugs by the P2 nucleoside transporter in Trypanosoma equiperdum

L Soulère; P Hoffmann; F Bringaud; J Périé

doi:10.1016/s0960-894x(00)00233-x

Synthesis and uptake of nitric oxide-releasing drugs by the P2 nucleoside transporter in Trypanosoma equiperdum

Bioorg Med Chem Lett. 2000 Jun 19;10(12):1347-50. doi: 10.1016/s0960-894x(00)00233-x.

Authors

L Soulère¹, P Hoffmann, F Bringaud, J Périé

Affiliation

¹ Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique-ESA-CNRS 5068, Université de Toulouse III, France.

PMID: 10890161
DOI: 10.1016/s0960-894x(00)00233-x

Abstract

A series of S-nitrosothiols, structurally related to the NO*-donor S-nitroso-N-acetylpenicillamine, and of organic nitrate esters that contain amidine groups which specify a recognition via the trypanosomal purine transporter P2, were synthesized and tested for their ability to inhibit the uptake of [2-(3)H]adenosine on Trypanosoma equiperdum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biological Transport
Carrier Proteins / metabolism*
Membrane Proteins / metabolism*
Nitric Oxide Donors / chemical synthesis*
Nitric Oxide Donors / metabolism
Nucleoside Transport Proteins
Purine Nucleosides / metabolism*
Trypanosoma / metabolism*

Substances

Carrier Proteins
Membrane Proteins
Nitric Oxide Donors
Nucleoside Transport Proteins
Purine Nucleosides